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B0681
Sigma
Anti-BACE 1, N-Terminus (46-62) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
| Synonym: | Anti-β-Site APP Cleaving Enzyme |
| MDL number: | MFCD03454775 |
Description
| Immunogen | synthetic peptide corresponding to the N-terminus of human BACE-1 (amino acids 46-62). |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide. |
Properties
| antibody form | affinity isolated antibody |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| mol wt | antigen mol wt 60-75 kDa |
| species reactivity | human |
| application(s) | immunoblotting: 1:1,000 using a whole cell extract from the human kidney HEK293 cell line stably transfected with human BACE-1 |
| Gene Information | human ... BACE1(23621) |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | NWG |
References
| reference | Behl, C., et al., Effects of sulindac sulfide on the membrane architecture and the activity of γ-secretase. Neuropharmacology 54, 998-1005, (2008) Abstract |
| Hitt, B., et al., β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer’s disease pathogenesis. J. Neurosci. 27, 3639-3649, (2007) Abstract | |
| Bollen, E., et al., Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay. Clin. Chem. 52, 1168-1174, (2006) Abstract |
